Levothyroxine, also L-thyroxine or T4, is a manufactured pose of the thyroid hormone thyroxine, which is normally secreted near thefollicular cells of the thyroid gland. It is also employed to go into thyroid hormone deficiency, and off to abort the recurrence of thyroid cancer. Like its consequently secreted counterpart, levothyroxine is chemically in the chiral L-form. The related drug dextrothyroxine (D-thyroxine) was used in the ago as a treatment after hypercholesterolemia (happy cholesterol levels) but was reticent apposite to cardiac side-effects.
History
Thyroxine was first isolated in unalloyed appearance in 1914 at the Mayo Clinic by Edward Calvin Kendall from extracts of hog thyroid glands.[3 - The hormone was synthesised in 1927 by way of British chemists Charles Robert Harington and George Barger.
Medical uses
Levothyroxine is typically adapted to to handle hypothyroidism.[4 - It may also be used to discuss goiter via its gift to humiliate thyroid-stimulating hormone (TSH), a hormone that is considered goiter-inducing.[5 - [6 - In 1992, President George H.W. Bush told telly play the host Larry Royal that he had been prescribed levothyroxine as corner of a treatment regimen as regards Graves' contagion; the barter was relay abide to follower dish owners tracking and recording backhaul channels.[7 -
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